Author Topic: Facial Turanism  (Read 1741 times)


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Re: Facial Turanism
« Reply #15 on: December 27, 2021, 08:43:38 pm »
Ancient common knowledge:

Although developmental biologists are used to thinking about the developing face as a receptacle for the embryonic brain — morphing and stretching as the growing brain pushes outward — it turns out that the face is an active participant in biological cross-talk during development that affects the three-dimensional features of both structures.
Scientists first linked the development of the face and brain in studies of some rare genetic conditions like holoprosencephaly, in which the brain doesn’t divide properly into two hemispheres. Affected people often also have facial malformations that run the gamut from mild to severe. But the true extent of the interaction between face and brain development among healthy people was unknown.
‘More overlap than we had expected’

They found 472 regions, or loci, in the genome that affect brain shape. Of these, 76 were previously shown to influence facial structure.

“This is more overlap than we had expected,” Wysocka said, “and it indicates that the face and brain shape are intertwined, not just in cases of malformation, but also in normal variation in healthy people.”

The 76 shared genetic regions include genes involved in well-known developmental pathways, as well as others that regulate the expression of other genes.

“When we started looking at these genes, we realized that the cross-talk that occurs between the face and the brain during development must be more complex than we previously realized,” Wysocka said. “Surprisingly, some of these genes are only known to be expressed in the face, and don’t have any known role or expression in the brain. So this implies that in addition to the brain influencing the facial shape, the face itself also affects the brain structure.”

Supporting this notion, genetic signals influencing brain shape are enriched in genomic regions regulating gene expression during embryogenesis, specifically in facial progenitor cells.