Author Topic: Vaccination  (Read 3068 times)

90sRetroFan

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Re: Vaccination
« Reply #45 on: September 06, 2022, 07:33:01 pm »
https://www.yahoo.com/news/yet-another-curveball-covid-mutation-084446293.html

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When the pharmaceutical industry scrambled to develop the first COVID vaccines back in 2020, it made sense that developers focused on the part of the virus that allows it to grab onto and infect our cells: the spike proteins.

The best vaccines contain a piece of the spike, or genetic data about the spike, either of which can spur an immune response. Not to be outdone, the virus has been mutating—with many of the changes occurring on that same spike.

But other parts of the virus are changing, too. Now, for the first time, a team of scientists has scrutinized these changes—and voiced a warning.

“With each major variant that has been identified, we are seeing mutations outside of [the] spike that we are trying to figure out,” Matthew Frieman, a University of Maryland School of Medicine immunologist and microbiologist and lead author of the new study, told The Daily Beast.

It’s possible the virus is accumulating non-spike mutations in an attempt to gain some advantage over our collective immunity as the COVID pandemic grinds toward its fourth year. These new mutations might not make the virus more infectious the way spike mutations do, but they could be associated with longer infections.

So have Western brains figured out what the problem is yet? Of course not, because Western brains are broken:

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If this trend continues—and there’s no reason to believe it won’t—we might eventually need new antiviral drugs and new vaccine formulations that aren’t so specifically focused on the spike.

THEN THE VIRUS WILL JUST GO BACK TO THE SPIKE! WHAT IS SO HARD TO UNDERSTAND ABOUT THIS?!

It's not that Western scientists, being scientists, don't understand what the virus is doing (they do, after initiating enough violence on innocent victims to do so):

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“Viruses don’t do things by accident.” Instead, they try out small changes, over and over, until some combination of changes helps it survive and spread. The resulting variant or subvariant then outcompetes other forms of the pathogen until it becomes dominant—and the likely basis for the next set of mutations.

To understand the reason for, and effects of, the non-spike mutations, Frieman’s team cloned SARS-CoV-2 then started deleting the spike proteins and testing the resulting “deletion viruses” on mice, assessing how contagious the viruses were and how severe the infections were.
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For now, it seems the spike and non-spike mutations are working together. The spike mutations make the virus steadily more contagious. “Mutations in [the] spike have been identified in every major variant that then out-competes the previous variant,” Frieman explained.

Meanwhile, the non-spike mutations appear to prolong infection. This in turn gives the pathogen more time to mutate inside a particular person, and also spread to other people. “We hypothesize that this balance is critical for further evolution of SARS-CoV-2,” Frieman’s team wrote.

It's that they, being Westerners, don't know any response besides mirroring what the virus is doing:

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Frieman said his goal is to scrutinize these non-spike mutations in order to “figure out what they do, how they do it [and] why they make the virus better at being a virus.” “Then we can use that information to make drugs,” including new antiviral therapies and vaccine formulations.

They even think that the solution is to go faster:

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Speed matters. The Omicron variant and its rapid-fire subvariants, each coming just a couple months after the last, was a warning that our pharmaceutical research-and-development processes might be too slow. Note that the U.S. Food and Drug Administration just last week green-lit Omicron-specific vaccine boosters—a full 10 months after the initial Omicron variant first became dominant. “Omicron and its lineages”—another term for subvariants—“taught us a lesson for the need to be more agile in modifying the vaccine,”

NO, THE MORE AGILE THE VACCINE BECOMES, THE MORE AGILE THE VIRUS BECOMES! THAT'S HOW PREDATOR-PREY DYNAMICS WORK!

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That problem could get worse if the rate of non-spike mutations accelerates. Our vaccine R&D is too slow even when it’s narrowly focused on the spike. What happens when it needs to broaden its scope to combat a virus that’s learning to mutate across its structure?

There’s another wrinkle. These accumulating mutations across the novel-coronavirus—on the spike and not on the spike—could start to mess with the polymerase chain-reaction tests we use to detect and track the virus.

PCR tests and sequencing use primers tailored for a certain range of viral characteristics. Too many mutations “can mess with the PCR test,” Niema Moshiri, a geneticist at the University of California-San Diego, told The Daily Beast.

Pay attention, but don’t panic. It’s really no surprise that SARS-CoV-2 is trying out mutations on different parts of the virus. That’s what viruses do—adapt.

Exactly. Yet read the next sentence:

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The trick for us, the novel-coronavirus’s host, is to adapt at least as quickly.



No, the trick is to stop thinking like a Westerner:

https://trueleft.createaforum.com/questions-debates/vaccination/msg10403/#msg10403

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Immunity approach = "We will evolve to be immune to you, and if you keep evolving in response, we will just keep evolving faster!"

Lockdown approach = "We will (by preventing transmissions) prevent you from evolving, so that we don't need to evolve either!"

The immunity approach is, at its core, a manifestation of progressivism (and hence equating the acquiring of more and more immunity with strengthening). The lockdown approach is a manifestation of regressivism (and hence equating the acquiring of more and more immunity with adulteration).

Regressivism must defeat progressivism if we are to break the cycle.

At least some comments are getting it now:

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Vaccines for SARS-CoV-2 and influenza will always be chasing these constantly evolving viral mutations, so the alternative is to also focus on the science involved in reducing transmission (primarily airborne via small infectious respiratory aerosols) in indoor settings.
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BTW the vaccines themselves exert evolutionary pressure on how these viruses evolve as they pass through the population.

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The vaccine is mutating this virus in my opinion.

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What we need is another full lockdown. Everyone I know is catching this. During the lockdown, the spread was much less.

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The mRNA vaccines are causing the mutations.

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Will anyone dare to hypothesize that the leaky vaccine is contributing to the variants?
« Last Edit: September 06, 2022, 07:48:11 pm by 90sRetroFan »